Phenotypes Associated with This Genotype

Genotype
MGI:5502380

• Allelic Composition: Cdkn2a^tm1.1Gsu/Cdkn2a^tm1.1Gsu; Kras^tm4Tyj/Kras⁺; Tg(Pdx1-cre)6Tuv/0
• Genetic Background: involves: 129S4/SvJae * 129S4/SvJaeSor * C57BL/6J * FVB/N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

premature death ( J:198619 )

• median survival 25.5 weeks

neoplasm

increased pancreas tumor incidence ( J:198619 )

• starting between 6 and 24 weeks with metastasis

increased pancreas adenoma incidence ( J:198619 )

• adenocarcinomas in 9 of 9 invasive carcinomas in the pancreas

increased pancreatic intraepithelial neoplasia incidence ( J:198619 )

increased adenocarcinoma incidence ( J:198619 )

• adenocarcinomas in 9 of 9 invasive carcinomas in the pancreas

growth/size/body

weight loss ( J:198619 )

• starting between 6 and 24 weeks

distended abdomen ( J:198619 )

• increased girth starting between 6 and 24 weeks

liver/biliary system

jaundice ( J:198619 )

• starting between 6 and 24 weeks

homeostasis/metabolism

ascites ( J:198619 )

• starting between 6 and 24 weeks

endocrine/exocrine glands

increased pancreas tumor incidence ( J:198619 )

• starting between 6 and 24 weeks with metastasis

increased pancreas adenoma incidence ( J:198619 )

• adenocarcinomas in 9 of 9 invasive carcinomas in the pancreas

increased pancreatic intraepithelial neoplasia incidence ( J:198619 )