Phenotypes for Brca2 Cd19 Trp53bp1 MGI:5495980 MGI Mouse

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Phenotypes Associated with This Genotype

Allelic Composition	Brca2^tm1Brn/Brca2^tm1Brn Trp53bp1^tm1Jc/Trp53bp1^tm1Jc Cd19^tm1(cre)Cgn/Cd19⁺
Genetic Background	involves: 129P2/OlaHsd

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Brca2^tm1Brn mutation (3 available); any Brca2 mutation (131 available)
Cd19^tm1(cre)Cgn mutation (12 available); any Cd19 mutation (57 available)
Trp53bp1^tm1Jc mutation (1 available); any Trp53bp1 mutation (100 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

cellular

chromosome breakage ( J:197442 )

• cells treated with PARP-inhibition exhibit increased chromosomal damage compared with cells from Brca2^tm1Brn/Brca2^tm1Brn Cd19^tm1(cre)Cgn/Cd19^tm1(cre)Cgn mice

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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