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Phenotypes Associated with This Genotype
Genotype
MGI:5494633
Allelic
Composition		 Hdac1tm1.1Mrl/Hdac1tm1.1Mrl
Hdac2tm1.1Rdp/Hdac2tm1.1Rdp
Tg(Mx1-cre)1Cgn/0
Genetic
Background		 involves: 129S4/SvJae * C57BL/6 * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hdac1tm1.1Mrl mutation (0 available); any Hdac1 mutation (38 available)
Hdac2tm1.1Rdp mutation (1 available); any Hdac2 mutation (39 available)
Tg(Mx1-cre)1Cgn mutation (10 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
premature death ( J:197818 )
• mice are moribund 9 days after pIpC treatment

hematopoietic system
anemia ( J:197818 )
• in pIpC-treated mice
decreased bone marrow cell number ( J:197818 )
• in pIpC-treated mice
decreased megakaryocyte cell number ( J:197818 )
• 20-fold in the bone marrow of pIpC-treated mice with increased apoptosis
decreased erythrocyte cell number ( J:197818 )
• 5-fold in pIpC-treated mice
thrombocytopenia ( J:197818 )
• 16-fold in pIpC-treated mice

cellular
increased apoptosis ( J:197818 )
• apoptotic megakaryocytes in pIpC-treated mice

behavior/neurological
lethargy ( J:197818 )
• in pIpC-treated mice

cardiovascular system
internal hemorrhage ( J:197818 )
• in pIpC-treated mice

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
01/06/2026
MGI 6.24 		The Jackson Laboratory