Phenotypes for Hdac1 Hdac2 Tg(Mx1-cre)1Cgn MGI:5494631 MGI Mouse

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Phenotypes Associated with This Genotype

Allelic Composition	Hdac1^tm1.1Mrl/Hdac1^tm1.1Mrl Hdac2^tm1.1Rdp/Hdac2⁺ Tg(Mx1-cre)1Cgn/0
Genetic Background	involves: 129S4/SvJae * C57BL/6 * CBA

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hdac1^tm1.1Mrl mutation (0 available); any Hdac1 mutation (38 available)
Hdac2^tm1.1Rdp mutation (1 available); any Hdac2 mutation (39 available)
Tg(Mx1-cre)1Cgn mutation (10 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

hematopoietic system

anemia ( J:197818 )

• in pIpC-treated mice

decreased bone marrow cell number ( J:197818 )

• in pIpC-treated mice

abnormal megakaryocyte morphology ( J:197818 )

• megakaryocytes from pIpC-treated mice exhibit aberrant nuclear morphology and mitotic figures and are frequently found intra-vascular or extravasating into bone marrow blood vessels and in the liver compared with control cells

decreased megakaryocyte cell number ( J:197818 )

• in the bone marrow of pIpC-treated mice without increased apoptosis

decreased erythrocyte cell number ( J:197818 )

• 2-fold in pIpC-treated mice

thrombocytopenia ( J:197818 )

• 6-fold in pIpC-treated mice

behavior/neurological

lethargy ( J:197818 )

• in pIpC-treated mice

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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