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Phenotypes Associated with This Genotype
Genotype
MGI:5491938
Allelic
Composition		 Cd74tm1Liz/Cd74tm1Liz
Sppl2atm1Basc/Sppl2atm1Basc
Genetic
Background		 B6.129-Sppl2atm1Basc Cd74tm1Liz
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cd74tm1Liz mutation (5 available); any Cd74 mutation (38 available)
Sppl2atm1Basc mutation (0 available); any Sppl2a mutation (46 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype

Sppl2atm1Basc/Sppl2atm1Basc Cd74tm1Liz/Cd74tm1Liz B cells show normal morphology compared to the increased vacuoles in Sppl2atm1Basc/Sppl2atm1Basc B cells

immune system
immune system phenotype ( J:194664 )
N
• B cells exhibit the same number of vacuoles per cells as wild-type mice and Cd74tm1Liz homozygotes
• calcium ion flux in T1 B cells is restored to normal
• B cell maturation and function are restored
• the size of Peyer's patches is restored
decreased B cell number ( J:194664 )
• compared with wild-type mice but improved from Sppl2atm1Basc homozygotes in the spleen and lymph nodes
decreased Peyer's patch number ( J:194664 )
• compared with wild-type mice but improved from Sppl2atm1Basc homozygotes

hematopoietic system
decreased B cell number ( J:194664 )
• compared with wild-type mice but improved from Sppl2atm1Basc homozygotes in the spleen and lymph nodes

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
03/25/2025
MGI 6.24 		The Jackson Laboratory