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Phenotypes Associated with This Genotype
Genotype
MGI:5491045
Allelic
Composition		 Eef1a1tm2Arge/Eef1a1+
Tg(Mx1-cre)1Cgn/0
Genetic
Background		 involves: C57BL/6 * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Eef1a1tm2Arge mutation (0 available); any Eef1a1 mutation (60 available)
Tg(Mx1-cre)1Cgn mutation (10 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
neoplasm
increased acute lymphoblastic leukemia incidence ( J:197167 )
• T cell acute lymphoblastic leukemia (T-ALL)
• progressive leukemic cells infiltrate the leptomeningeal spaces of the brain

immune system
abnormal double-positive T cell morphology ( J:197167 )
• atypical CD4+CD8+ T cells in the peripheral blood

hematopoietic system
abnormal double-positive T cell morphology ( J:197167 )
• atypical CD4+CD8+ T cells in the peripheral blood

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
01/06/2026
MGI 6.24 		The Jackson Laboratory