Mouse Genome Informatics
cn
    Ptentm1Hwu/Ptentm1Hwu
Tg(KRT14-cre/ERT)20Efu/0
Tgfbr1tm1.1Karl/Tgfbr1tm1.1Karl

involves: 129 * 129S4/SvJae * C57BL/6 * CD-1 * FVB/N
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
       
tumorigenesis
• tamoxifen treated mutants to induce cre-mediated deletion of Tgfbr1 and Pten develop head and neck tumors; papillomas progress to squamous cell carcinoma in the head and neck and oral cavity
• treatment with rapamycin 2 weeks after tamoxifen administration delays initiation and reduces progression of papilloma and onset of squamous cell carcinoma
• rapamycin treatment of mice with already established head and neck squamous cell carcinoma results in regression of those tumors; rapamycin decreases cell proliferation and increases apoptosis in these tumors
• tamoxifen treated mutants to induce cre-mediated deletion of Tgfbr1 and Pten develop head and neck and oral cavity papillomas that progress to squamous cell carcinoma

Mouse Models of Human Disease
OMIM IDRef(s)
Squamous Cell Carcinoma, Head and Neck; HNSCC 275355 J:194652