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Phenotypes Associated with This Genotype
Genotype
MGI:5487549
Allelic
Composition		 Slc4a2tm2Ges/Slc4a2tm2Ges
Tg(Mx1-cre)1Cgn/0
Genetic
Background		 involves: C57BL/6 * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Slc4a2tm2Ges mutation (0 available); any Slc4a2 mutation (53 available)
Tg(Mx1-cre)1Cgn mutation (10 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype

Increased bone mass in polyI:C treated Slc4a2tm2Ges/Slc4a2tm2Ges Tg(Mx1-cre)1Cgn/0 mice

skeleton
abnormal osteoclast morphology ( J:193823 )
• enlarged following polyI:C treatment
abnormal osteoclast physiology ( J:193823 )
• impaired attachment to bone surfaces following polyI:C treatment
• abnormal spreading and reduced calpain activity in vitro following polyI:C treatment
increased bone mass ( J:193823 )
• following polyI:C treatment

immune system
abnormal osteoclast morphology ( J:193823 )
• enlarged following polyI:C treatment
abnormal osteoclast physiology ( J:193823 )
• impaired attachment to bone surfaces following polyI:C treatment
• abnormal spreading and reduced calpain activity in vitro following polyI:C treatment

hematopoietic system
abnormal osteoclast morphology ( J:193823 )
• enlarged following polyI:C treatment
abnormal osteoclast physiology ( J:193823 )
• impaired attachment to bone surfaces following polyI:C treatment
• abnormal spreading and reduced calpain activity in vitro following polyI:C treatment

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
01/06/2026
MGI 6.24 		The Jackson Laboratory