Slc4a2^tm2Ges
Targeted Allele Detail

Summary

• Symbol: Slc4a2^tm2Ges
• Name: solute carrier family 4 (anion exchanger), member 2; targeted mutation 2, Gary E Shull
• MGI ID: MGI:5487545
• Synonyms: Slc4a2^fl
• Gene: Slc4a2 Location: Chr5:24628939-24645945 bp, + strand Genetic Position: Chr5, 11.74 cM
• Alliance: Slc4a2^tm2Ges page

Enlarged osteoclasts that poorly attach to bone surfaces in Slc4a2^tm2Ges/Slc4a2^tm2Ges Tg(Mx1-cre)1Cgn/0 mice

Show the 3 phenotype image(s) involving this allele.

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:193823
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Exon 8 was flanked with loxP sites. (J:193823)

Expression

In Structures Affected by this Mutation:

4 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Slc4a2 Mutation: 53 strains or lines available

References

• Original: J:193823 Coury F, et al., SLC4A2-mediated Cl-/HCO3- exchange activity is essential for calpain-dependent regulation of the actin cytoskeleton in osteoclasts. Proc Natl Acad Sci U S A. 2013 Feb 5;110(6):2163-8
• All: 5 reference(s)