Phenotypes Associated with This Genotype

Genotype
MGI:5486056

• Allelic Composition: Kras^tm4Tyj/Kras⁺; Sftpc^{tm1.1(cre/ERT2)Ptch}/Sftpc⁺
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * FVB

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

neoplasm

increased lung adenoma incidence ( J:195738 )

• by 18 weeks after tamoxifen treatment, numerous adenomas develop in alveoli; small numbers of cells with features of malignant transformation are observed in some lung sections

• tumors are usually found in proximity to the airways, bronchioalveolar duct junctions (BADJs), or surface of the lung, but lesions are not found in the BADJs

• tumor cells are highly proliferative

• airways and BADJs retain normal architecture

respiratory system

increased lung adenoma incidence ( J:195738 )

• by 18 weeks after tamoxifen treatment, numerous adenomas develop in alveoli; small numbers of cells with features of malignant transformation are observed in some lung sections

• tumors are usually found in proximity to the airways, bronchioalveolar duct junctions (BADJs), or surface of the lung, but lesions are not found in the BADJs

• tumor cells are highly proliferative

• airways and BADJs retain normal architecture