Phenotypes Associated with This Genotype

Genotype
MGI:5485355

• Allelic Composition: Nf1^tm1Fcr/Nf1⁺; Trp53^tm1Brd/Trp53⁺
• Genetic Background: B6.129-Trp53^tm1Brd Nf1^tm1Fcr

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

nervous system

increased brain tumor incidence ( J:95933 )

• develop sarcomas and brain tumors as early as 15 weeks of age

mortality/aging

decreased tumor-free survival time ( J:95933 )

• mice that develop malignant tumors die by 26 weeks of age

neoplasm

increased malignant tumor incidence ( J:95933 )

• 11 of 19 (57.9%) mice develop malignant tumors and die by 26 weeks of age

increased sarcoma incidence ( J:95933 )

• develop sarcomas and brain tumors as early as 15 weeks of age

increased brain tumor incidence ( J:95933 )

• develop sarcomas and brain tumors as early as 15 weeks of age