About   Help   FAQ
Phenotypes Associated with This Genotype
Genotype
MGI:5473567
Allelic
Composition		 Msx1tm2.1(cre/ERT2)Bero/Msx1tm1Bero
Genetic
Background		 involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Msx1tm1Bero mutation (1 available); any Msx1 mutation (18 available)
Msx1tm2.1(cre/ERT2)Bero mutation (2 available); any Msx1 mutation (18 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
embryo
abnormal embryonic tissue morphology ( J:194129 )
• internal organ development is disrupted due to thoracoabdominoschisis

growth/size/body
abnormal facial morphology ( J:194129 )
• at E12.5, embryos have highly deformed faces
thoracoabdominoschisis ( J:194129 )
• at E12.3 embryos show thoracoabdominoschisis (opening of both the thorax and abdomen)

craniofacial
abnormal facial morphology ( J:194129 )
• at E12.5, embryos have highly deformed faces

nervous system
exencephaly ( J:194129 )
• at E12.5

liver/biliary system
abnormal liver development ( J:194129 )
• liver appears rudimentary

vision/eye
abnormal eye morphology ( J:194129 )
• embryos display atrophic eyes at E12.5

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
03/18/2025
MGI 6.24 		The Jackson Laboratory