Mouse Genome Informatics
cn
    Insrtm1Khn/Insrtm1Khn
Leprtm1.1Chua/Leprtm1.1Chua
Tg(Pomc1-cre)16Lowl/0

involves: 129 * 129S4/SvJae * 129S6/SvEvTac * C57BL/6J * FVB/N
Key:
phenotype observed in females
phenotype observed in males
N normal phenotype
adipose tissue
• macrophage marker analysis indicates low-grade inflammation in adipose tissue
• percent body fat is increased in females at 4 months of age, however absolute body weight is not increased at this time
• trend towards increased intra-abdominal adiposity at 4 months of age
• perigonadal adipocyte hypertrophy at 4 months of age
• perigonadal adipocyte hypertrophy at 4 months of age
• an increase in macrophage accumulation is seen in the perigonadal fat indicating inflammation

endocrine/exocrine glands
• 45% of mice lack either corpora lutea or preovulatory follicles
• 45% of mice lack either corpora lutea or preovulatory follicles
• low-grade inflammation as indicated by increased IL-6 expression in the ovary

growth/size/body
• percent body fat is increased in females at 4 months of age, however absolute body weight is not increased at this time
• percent lean body mass is decreased at 4 months of age

homeostasis/metabolism
• females are hyperglycemic before (at 3 months of age) and during pregnancy (at gestational days 12 and 15), without evidence of gestational glucose intolerance
• circulating levels of adipokine leptin are increased at 4 months of age

immune system
• an increase in macrophage accumulation is seen in the perigonadal fat, and macrophage marker analysis and cytokine expression indicates low-grade inflammation in adipose tissue
• low-grade inflammation is also observed in ovary and liver based on cytokine expression analysis
• low-grade inflammation as indicated by increased IL-6 expression in the ovary
• low-grade inflammation as indicated by increased IL-1beta expression in the liver

liver/biliary system
• low-grade inflammation as indicated by increased IL-1beta expression in the liver

reproductive system
• 45% of mice lack either corpora lutea or preovulatory follicles
• 45% of mice lack either corpora lutea or preovulatory follicles
• low-grade inflammation as indicated by increased IL-6 expression in the ovary
• females exhibit reduced ovulation but show normal cycling suppression from fasting

Mouse Models of Human Disease
OMIM IDRef(s)
Polycystic Ovary Syndrome 1; PCOS1 184700 J:192274