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Phenotypes Associated with This Genotype
Genotype
MGI:5471586
Allelic
Composition
Insrtm1Khn/Insrtm1Khn
Leprtm1.1Chua/Leprtm1.1Chua
Tg(Pomc1-cre)16Lowl/0
Genetic
Background
involves: 129 * 129S4/SvJae * 129S6/SvEvTac * C57BL/6J * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Insrtm1Khn mutation (1 available); any Insr mutation (45 available)
Leprtm1.1Chua mutation (0 available); any Lepr mutation (59 available)
Tg(Pomc1-cre)16Lowl mutation (1 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
adipose tissue
• macrophage marker analysis indicates low-grade inflammation in adipose tissue
• trend towards increased intra-abdominal adiposity at 4 months of age
• perigonadal adipocyte hypertrophy at 4 months of age
• perigonadal adipocyte hypertrophy at 4 months of age
• an increase in macrophage accumulation is seen in the perigonadal fat indicating inflammation
• percent body fat is increased in females at 4 months of age, however absolute body weight is not increased at this time

endocrine/exocrine glands
• 45% of mice lack either corpora lutea or preovulatory follicles
• 45% of mice lack either corpora lutea or preovulatory follicles
• low-grade inflammation as indicated by increased IL-6 expression in the ovary

growth/size/body
• percent lean body mass is decreased at 4 months of age

homeostasis/metabolism
• females are hyperglycemic before (at 3 months of age) and during pregnancy (at gestational days 12 and 15), without evidence of gestational glucose intolerance
• circulating levels of adipokine leptin are increased at 4 months of age

immune system
• an increase in macrophage accumulation is seen in the perigonadal fat, and macrophage marker analysis and cytokine expression indicates low-grade inflammation in adipose tissue
• low-grade inflammation is also observed in ovary and liver based on cytokine expression analysis
• low-grade inflammation as indicated by increased IL-6 expression in the ovary
• low-grade inflammation as indicated by increased IL-1beta expression in the liver

liver/biliary system
• low-grade inflammation as indicated by increased IL-1beta expression in the liver

reproductive system
• 45% of mice lack either corpora lutea or preovulatory follicles
• 45% of mice lack either corpora lutea or preovulatory follicles
• low-grade inflammation as indicated by increased IL-6 expression in the ovary
• females exhibit reduced ovulation but show normal cycling suppression from fasting

Mouse Models of Human Disease
OMIM ID Ref(s)
Polycystic Ovary Syndrome 1; PCOS1 184700 J:192274


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
06/15/2016
MGI 6.04
The Jackson Laboratory