About   Help   FAQ
Phenotypes Associated with This Genotype
Genotype
MGI:5468652
Allelic
Composition		 Ccnd3tm1Pisc/Ccnd3tm1Pisc
Rb1tm2Brn/Rb1tm2Brn
Tg(Mx1-cre)1Cgn/0
Genetic
Background		 involves: 129 * C57BL/6 * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ccnd3tm1Pisc mutation (0 available); any Ccnd3 mutation (507 available)
Rb1tm2Brn mutation (3 available); any Rb1 mutation (106 available)
Tg(Mx1-cre)1Cgn mutation (7 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
decreased T cell proliferation ( J:192031 )
• of pre-T cells as in Ccnd3tm1Pisc homozygotes
thymus hypoplasia ( J:192031 )
• not as severe as in pIpC-treated mice as in Ccnd3tm1Pisc homozygotes
decreased double-positive T cell number ( J:192031 )
• as in Ccnd3tm1Pisc homozygotes

hematopoietic system
decreased T cell proliferation ( J:192031 )
• of pre-T cells as in Ccnd3tm1Pisc homozygotes
thymus hypoplasia ( J:192031 )
• not as severe as in pIpC-treated mice as in Ccnd3tm1Pisc homozygotes
decreased double-positive T cell number ( J:192031 )
• as in Ccnd3tm1Pisc homozygotes

endocrine/exocrine glands
thymus hypoplasia ( J:192031 )
• not as severe as in pIpC-treated mice as in Ccnd3tm1Pisc homozygotes

cellular
decreased T cell proliferation ( J:192031 )
• of pre-T cells as in Ccnd3tm1Pisc homozygotes

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
04/30/2024
MGI 6.23 		The Jackson Laboratory