Phenotypes Associated with This Genotype

Genotype
MGI:5464101

• Allelic Composition: Map3k7^tm1Aki/Map3k7^tm1Aki; Tg(Tek-cre)12Flv/0
• Genetic Background: involves: 129P2/OlaHsd * C3H * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

embryonic lethality during organogenesis, complete penetrance ( J:191285 )

• mice die between E10.5 and E11.5

cardiovascular system

cardiovascular system phenotype ( J:191285 )

N • mice exhibit normal cardiac development

abnormal vascular development ( J:191285 )

• defective vascular development at E10.5 with disorganized vasculature and truncated capillary vessels

• however, development of the aorta is normal

decreased angiogenesis ( J:191285 )

• impaired vessel sprouting

abnormal vitelline vasculature morphology ( J:191285 )

• fewer vessel branches

embryo

abnormal vitelline vasculature morphology ( J:191285 )

• fewer vessel branches

cellular

increased apoptosis ( J:191285 )

• in embryonic endothelial cell