Phenotypes for Calca Pten Rb1 Trp53 MGI:5460854 MGI Mouse

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Phenotypes Associated with This Genotype

Allelic Composition	Calca^{tm1.1(cre/ERT2)Ptch}/Calca⁺ Trp53^tm1Brn/Trp53^tm1Brn Rb1^tm2Brn/Rb1^tm2Brn Pten^tm1Hwu/Pten^tm1Hwu
Genetic Background	involves: 129 * 129P2/OlaHsd * 129S4/SvJae * BALB/c * FVB/N

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Calca^{tm1.1(cre/ERT2)Ptch} mutation (0 available); any Calca mutation (24 available)
Pten^tm1Hwu mutation (17 available); any Pten mutation (86 available)
Rb1^tm2Brn mutation (2 available); any Rb1 mutation (116 available)
Trp53^tm1Brn mutation (20 available); any Trp53 mutation (237 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

postnatal lethality ( J:190366 )

• death within 3 months of tamoxifen treatment

respiratory system

increased lung small cell carcinoma incidence ( J:190366 )

• small cell lung tumors 2.5 months after tamoxifen treatment

abnormal pulmonary neuroendocrine body morphology ( J:190366 )

• increased proliferation of pulmonary neuroendocrine cells

neoplasm

increased thyroid tumor incidence ( J:190366 )

• all mice develop thyroid tumors

increased metastatic potential ( J:190366 )

• increased invasiveness at 2.5 months after tamoxifen treatment

increased lung small cell carcinoma incidence ( J:190366 )

• small cell lung tumors 2.5 months after tamoxifen treatment

endocrine/exocrine glands

increased thyroid tumor incidence ( J:190366 )

• all mice develop thyroid tumors

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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