Phenotypes Associated with This Genotype

Genotype
MGI:5446891

• Allelic Composition: Ctnnb1^tm1Mmt/Ctnnb1^tm1Mmt; Tcf21^tm1(cre)Seq/Tcf21⁺
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

neonatal lethality ( J:189643 )

• mutants are born in expected numbers but die within hours of birth

renal/urinary system

kidney cyst ( J:189643 )

• rudimentary kidneys are cystic with only a only a few immature glomeruli and show random disorganized nephrogenic aggregates at periphery

abnormal kidney development ( J:189643 )

• about 20% of E18.5 embryos or neonatal pups exhibit hypoplastic rudimentary kidneys

renal hypoplasia ( J:189643 )

• most kidneys show some degree of hypoplasia

hydroureter ( J:189643 )

• hydroureter with hypoplasia is observed at E18.5 and in PO pups with about 73.5% incidence; these kidneys also exhibit dilated tubules

ureter hypoplasia ( J:189643 )

growth/size/body

kidney cyst ( J:189643 )

• rudimentary kidneys are cystic with only a only a few immature glomeruli and show random disorganized nephrogenic aggregates at periphery