Phenotypes for Cd19 Map3k14 Tbk1 MGI:5446431 MGI Mouse

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Phenotypes Associated with This Genotype

Allelic Composition	Tbk1^tm1Arte/Tbk1^tm1Arte Map3k14^tm1Rds/Map3k14^tm1Rds Cd19^tm1(cre)Cgn/Cd19⁺
Genetic Background	involves: 129/SvEv * 129P2/OlaHsd * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cd19^tm1(cre)Cgn mutation (12 available); any Cd19 mutation (57 available)
Map3k14^tm1Rds mutation (1 available); any Map3k14 mutation (42 available)
Tbk1^tm1Arte mutation (0 available); any Tbk1 mutation (57 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

abnormal B cell differentiation ( J:188560 )

• no significant increase in the production of IgA+ compared to mice homozygous for Map3k14^tm1Rds alone

abnormal immunoglobulin level ( J:188560 )

• unlike mutant mice wild-type for Map3k14 the serum titer of IgA is not elevated

hematopoietic system

abnormal B cell differentiation ( J:188560 )

• no significant increase in the production of IgA+ compared to mice homozygous for Map3k14^tm1Rds alone

abnormal immunoglobulin level ( J:188560 )

• unlike mutant mice wild-type for Map3k14 the serum titer of IgA is not elevated

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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