Phenotypes Associated with This Genotype

Genotype
MGI:5446428

• Allelic Composition: Tbk1^tm1Arte/Tbk1^tm1Arte; Cd19^tm1(cre)Cgn/Cd19⁺
• Genetic Background: involves: 129/SvEv * 129P2/OlaHsd * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

increased mature B cell number ( J:188560 )

• much greater frequency of IgA+ B cells in mesenteric lymph nodes and Peyer's patches compared to age matched controls

• significantly greater frequency and number of IgA+ B cells in the spleen in young mice immunized with a T cell dependent antigen

abnormal B cell physiology ( J:188560 )

• moderate increase in NKKB activation following induction

abnormal class switch recombination ( J:188560 )

• expression analysis indicates a defect in the negative regulation of class switching to IgA

increased IgA level ( J:188560 )

• production of antigen specific IgA in immunized mice is enhanced compared to similarly treated controls

• starting at 12 weeks of age serum IgA levels are increased in unimmunized mice compared to aged match controls

increased IgM level ( J:188560 )

• production of antigen specific IgM in immunized mice is moderately enhanced compared to similarly treated controls

increased anti-nuclear antigen antibody level ( J:188560 )

• higher serum titers of the autoantibody antinuclear antigen at 8 months of age

increased anti-double stranded DNA antibody level ( J:188560 )

• at 8 months of age

renal/urinary system

increased urine protein level ( J:188560 )

• at 8 months of age

abnormal kidney physiology ( J:188560 )

• prominent deposition of antibodies in the kidney glomeruli at 8 months of age a sign of nephropathy

homeostasis/metabolism

increased circulating creatinine level ( J:188560 )

• at 8 months of age

increased blood urea nitrogen level ( J:188560 )

• at 8 months of age

increased urine protein level ( J:188560 )

• at 8 months of age

hematopoietic system

increased mature B cell number ( J:188560 )

• much greater frequency of IgA+ B cells in mesenteric lymph nodes and Peyer's patches compared to age matched controls

• significantly greater frequency and number of IgA+ B cells in the spleen in young mice immunized with a T cell dependent antigen

abnormal B cell physiology ( J:188560 )

• moderate increase in NKKB activation following induction

abnormal class switch recombination ( J:188560 )

• expression analysis indicates a defect in the negative regulation of class switching to IgA

increased IgA level ( J:188560 )

• production of antigen specific IgA in immunized mice is enhanced compared to similarly treated controls

• starting at 12 weeks of age serum IgA levels are increased in unimmunized mice compared to aged match controls

increased IgM level ( J:188560 )

• production of antigen specific IgM in immunized mice is moderately enhanced compared to similarly treated controls