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Phenotypes Associated with This Genotype
Genotype
MGI:5445987
Allelic
Composition
Gt(ROSA)26Sortm1(EYFP)Cos/Gt(ROSA)26Sor+
S1pr1tm2Rlp/S1pr1tm2Rlp
Tg(Cdh5-cre/ERT2)1Rha/0
Genetic
Background
involves: 129S6/SvEvTac * 129X1/SvJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sortm1(EYFP)Cos mutation (24 available); any Gt(ROSA)26Sor mutation (1062 available)
S1pr1tm2Rlp mutation (2 available); any S1pr1 mutation (29 available)
Tg(Cdh5-cre/ERT2)1Rha mutation (5 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
cardiovascular system
• glomeruloid lesions form when tamoxifen is administered throughout pregnancy, although these lesions are less severe than in germ line null mice
• endothelial hyper-sprouting and retention of mural cell coverage on arteries and veins are detected after tamoxifen treatment

vision/eye
• endothelial hyper-sprouting and retention of mural cell coverage on arteries and veins are detected after tamoxifen treatment


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Funding Information
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last database update
01/06/2026
MGI 6.24
The Jackson Laboratory