Phenotypes Associated with This Genotype

Genotype
MGI:5442608

• Allelic Composition: Gt(ROSA)26Sor^tm1(EYFP)Cos/Gt(ROSA)26Sor⁺; Cd19^tm1(cre)Cgn/Cd19⁺; Rev3l^tm1.1Diaz/Rev3l^tm1.1Diaz
• Genetic Background: involves: 129P2/OlaHsd * 129X1/SvJ * BALB/c * C57BL/6 * C57BL/6NTac

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

immune system phenotype ( J:188723 )

N • mice exhibit normal B cell development in the bone marrow and spleen

decreased B cell proliferation ( J:188723 )

• following with activation LPS, less so when activated with LPS plus IL4

abnormal class switch recombination ( J:188723 )

• following activated with LPS and IL4, mice exhibit decreased IgG1+ cells, indicating reduced class switch recombination, compared with wild-type mice

abnormal somatic hypermutation frequency ( J:188723 )

• following immunization with NP-CGG in alum, splenic B cells exhibit reduced mutation frequency in the rearranged Vh186.2 H chains compared with wild-type cells

• Peyer's patch B cells exhibit reduced accumulation of mutation at the intron downstream of rearranged V genes compared with wild-type cells

hematopoietic system

decreased B cell proliferation ( J:188723 )

• following with activation LPS, less so when activated with LPS plus IL4

abnormal class switch recombination ( J:188723 )

• following activated with LPS and IL4, mice exhibit decreased IgG1+ cells, indicating reduced class switch recombination, compared with wild-type mice

abnormal somatic hypermutation frequency ( J:188723 )

• following immunization with NP-CGG in alum, splenic B cells exhibit reduced mutation frequency in the rearranged Vh186.2 H chains compared with wild-type cells

• Peyer's patch B cells exhibit reduced accumulation of mutation at the intron downstream of rearranged V genes compared with wild-type cells

cellular

decreased B cell proliferation ( J:188723 )

• following with activation LPS, less so when activated with LPS plus IL4