Phenotypes Associated with This Genotype

Genotype
MGI:5441341

• Allelic Composition: Hbb-b1^tm1Unc/Hbb-b1⁺; Hbb-b2^tm1Unc/Hbb-b2⁺; Tmprss6^tm1Otin/Tmprss6^tm1Otin
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * C57BL/6N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

hematopoietic system

abnormal erythroid progenitor cell morphology ( J:185154 )

• reduced percentage in the spleen compared to mutant mice wild-type for Tmprss6

abnormal erythrocyte morphology ( J:185154 )

• abnormalities are ameliorated compared to mutant mice wild-type for Tmprss6

abnormal erythropoiesis ( J:185154 )

• improved erythropoiesis compared to mutant mice wild-type for Tmprss6

abnormal erythrocyte cell number ( J:185154 )

• increased by about 30% compared to mutant mice wild-type for Tmprss6

abnormal hemoglobin content ( J:185154 )

• increased by about 15% compared to mutant mice wild-type for Tmprss6

reticulocytopenia ( J:185154 )

• reduced percentage compared to mutant mice wild-type for Tmprss6

abnormal spleen size ( J:185154 )

• reduced size compared to mutant mice wild-type for Tmprss6

homeostasis/metabolism

homeostasis/metabolism phenotype ( J:185154 )

N • iron levels in the spleen and liver are similar to wild-type controls unlike in mutant mice wild-type for Tmprss6

increased circulating erythropoietin level ( J:185154 )

• similar to mutant mice wild-type for Tmprss6

• levels are higher in males than in females

immune system

abnormal spleen size ( J:185154 )

• reduced size compared to mutant mice wild-type for Tmprss6