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Phenotypes Associated with This Genotype
Genotype
MGI:5432232
Allelic
Composition
Amhr2tm3(cre)Bhr/Amhr2+
Ctnnb1tm1Mmt/Ctnnb1+
Ptentm1Hwu/Ptentm1Hwu
Genetic
Background
involves: 129S4/SvJae * 129S7/SvEvBrd * 129X1/SvJ * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Amhr2tm3(cre)Bhr mutation (1 available); any Amhr2 mutation (9 available)
Ctnnb1tm1Mmt mutation (0 available); any Ctnnb1 mutation (17 available)
Ptentm1Hwu mutation (3 available); any Pten mutation (37 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
tumorigenesis
• female mutants develop granulosa cell tumors by 3 weeks of age (J:186144)
• female mutants develop granulosa cell tumors by 3 weeks of age (J:186144)
• male mutants develop testicular granulosa cell tumors by 5 weeks of age (J:186144)
• male mutants develop testicular granulosa cell tumors by 5 weeks of age (J:186144)

Mouse Models of Human Disease
OMIM ID Ref(s)
Ovarian Cancer 167000 J:186144


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
01/26/2016
MGI 6.02
The Jackson Laboratory