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Phenotypes Associated with This Genotype
Genotype
MGI:5432231
Allelic
Composition
Ctnnb1tm1Mmt/Ctnnb1+
Krastm4Tyj/Kras+
Amhr2tm3(cre)Bhr/Amhr2+
Genetic
Background
involves: 129S4/SvJae * 129S7/SvEvBrd * 129X1/SvJ * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Amhr2tm3(cre)Bhr mutation (1 available); any Amhr2 mutation (14 available)
Ctnnb1tm1Mmt mutation (0 available); any Ctnnb1 mutation (28 available)
Krastm4Tyj mutation (4 available); any Kras mutation (32 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
neoplasm
• female mutants develop granulosa cell tumors by 12-14 weeks of age
• male mutants develop granulosa cell tumors of the testis by 4-5 months of age; tumors do not spread or metastasize

reproductive system
• seminiferous tubule degeneration is seen by 4 weeks of age
• female mutants develop granulosa cell tumors by 12-14 weeks of age
• male mutants develop granulosa cell tumors of the testis by 4-5 months of age; tumors do not spread or metastasize

endocrine/exocrine glands
• seminiferous tubule degeneration is seen by 4 weeks of age
• female mutants develop granulosa cell tumors by 12-14 weeks of age
• male mutants develop granulosa cell tumors of the testis by 4-5 months of age; tumors do not spread or metastasize

Mouse Models of Human Disease
OMIM ID Ref(s)
Ovarian Cancer 167000 J:186144


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
11/22/2016
MGI 6.06
The Jackson Laboratory