Mouse Genome Informatics
cn
    Ctnnb1tm1Mmt/Ctnnb1+
Krastm4Tyj/Kras+
Amhr2tm3(cre)Bhr/Amhr2+

involves: 129S4/SvJae * 129S7/SvEvBrd * 129X1/SvJ * C57BL/6
Key:
phenotype observed in females
phenotype observed in males
N normal phenotype
tumorigenesis
• female mutants develop granulosa cell tumors by 12-14 weeks of age
• male mutants develop granulosa cell tumors of the testis by 4-5 months of age; tumors do not spread or metastasize

reproductive system
• seminiferous tubule degeneration is seen by 4 weeks of age

endocrine/exocrine glands
• seminiferous tubule degeneration is seen by 4 weeks of age

Mouse Models of Human Disease
OMIM IDRef(s)
Ovarian Cancer 167000 J:186144