Mouse Genome Informatics
cn
    Ctnnb1tm1Mmt/Ctnnb1+
Krastm4Tyj/Kras+
Amhr2tm3(cre)Bhr/Amhr2+

involves: 129S4/SvJae * 129S7/SvEvBrd * 129X1/SvJ * C57BL/6
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
       
tumorigenesis
• female mutants develop granulosa cell tumors by 12-14 weeks of age (J:186144)
• male mutants develop granulosa cell tumors of the testis by 4-5 months of age; tumors do not spread or metastasize (J:186144)

reproductive system
• seminiferous tubule degeneration is seen by 4 weeks of age (J:186144)

endocrine/exocrine glands
• seminiferous tubule degeneration is seen by 4 weeks of age (J:186144)

Mouse Models of Human Disease
OMIM IDRef(s)
Ovarian Cancer 167000 J:186144