About   Help   FAQ
Phenotypes Associated with This Genotype
Genotype
MGI:5430376
Allelic
Composition
Taf7tm1.1Dss/Taf7tm1.2Dss
Tg(Cd8a*-cre)B8Asin/0
Genetic
Background
involves: C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Taf7tm1.1Dss mutation (0 available); any Taf7 mutation (17 available)
Taf7tm1.2Dss mutation (0 available); any Taf7 mutation (17 available)
Tg(Cd8a*-cre)B8Asin mutation (1 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
• after stimulation with either anti-CD3epsilon or a combination of anti-CD3 epsilon and anti-CD28 antibodies in the presence or absence of IL2
• modest effect on T cell development
• however, mice exhibit normal differentiation from double positive to single positive thymocyte and differentiation of single positive thymocytes
• in the lymph nodes
• at the double positive stage

hematopoietic system
• after stimulation with either anti-CD3epsilon or a combination of anti-CD3 epsilon and anti-CD28 antibodies in the presence or absence of IL2
• modest effect on T cell development
• however, mice exhibit normal differentiation from double positive to single positive thymocyte and differentiation of single positive thymocytes
• in the lymph nodes
• at the double positive stage

endocrine/exocrine glands
• at the double positive stage

cellular
• after stimulation with either anti-CD3epsilon or a combination of anti-CD3 epsilon and anti-CD28 antibodies in the presence or absence of IL2


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support.
last database update
12/30/2025
MGI 6.24
The Jackson Laboratory