Phenotypes Associated with This Genotype

Genotype
MGI:5430375

• Allelic Composition: Taf7^tm1.1Dss/Taf7^tm1.2Dss; Tg(Lck-cre)1Cwi/0
• Genetic Background: involves: C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

small thymus ( J:185745 )

• very small

decreased thymocyte number ( J:185745 )

abnormal thymus physiology ( J:185745 )

• double negative thymocytes exhibit impaired proliferation

abnormal T cell differentiation ( J:185745 )

• mice exhibit defects in the transition from double negative to double positive thymocytes

increased double-negative T cell number ( J:185745 )

• slightly in the thymus

decreased double-positive T cell number ( J:185745 )

• in the thymus

decreased CD4-positive, alpha-beta T cell number ( J:185745 )

• in the thymus and spleen

decreased CD8-positive, alpha-beta T cell number ( J:185745 )

• in the thymus and spleen

hematopoietic system

small thymus ( J:185745 )

• very small

decreased thymocyte number ( J:185745 )

abnormal thymus physiology ( J:185745 )

• double negative thymocytes exhibit impaired proliferation

abnormal T cell differentiation ( J:185745 )

• mice exhibit defects in the transition from double negative to double positive thymocytes

increased double-negative T cell number ( J:185745 )

• slightly in the thymus

decreased double-positive T cell number ( J:185745 )

• in the thymus

decreased CD4-positive, alpha-beta T cell number ( J:185745 )

• in the thymus and spleen

decreased CD8-positive, alpha-beta T cell number ( J:185745 )

• in the thymus and spleen

endocrine/exocrine glands

small thymus ( J:185745 )

• very small

decreased thymocyte number ( J:185745 )

abnormal thymus physiology ( J:185745 )

• double negative thymocytes exhibit impaired proliferation