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Phenotypes Associated with This Genotype
Genotype
MGI:5428914
Allelic
Composition
Tg(Pklr-Myc)73Ak/0
Genetic
Background
involves: C57BL/6 * DBA
Find Mice Using the International Mouse Strain Resource (IMSR)
No mouse lines available in IMSR.
See publication links below for author information.
phenotype observed in females
phenotype observed in males
N normal phenotype
liver/biliary system
• mutants fed a carbohydrate-rich diet develop hepatocarcinomas
• frequency of hepatocarcinomas is positively correlated with the carbohydrate content of the diet; frequency increases from 14.3% to 31.7% and 65.2% when the carbohydrate ratio is increased from 10% to 50% to 75%, respectively
• mutants fed a carbohydrate-rich diet frequently develop hepatomas

neoplasm
• mutants fed a carbohydrate-rich diet develop hepatocarcinomas
• frequency of hepatocarcinomas is positively correlated with the carbohydrate content of the diet; frequency increases from 14.3% to 31.7% and 65.2% when the carbohydrate ratio is increased from 10% to 50% to 75%, respectively
• mutants fed a carbohydrate-rich diet frequently develop hepatomas

endocrine/exocrine glands
• mutants fed a carbohydrate-rich diet exhibit pancreatic islet hyperplasia, however they do not develop pancreatic tumors

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
hepatocellular carcinoma DOID:684 OMIM:114550
J:185488


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
11/05/2019
MGI 6.14
The Jackson Laboratory