Mouse Genome Informatics
hm
    Nrxn1tm1Sud/Nrxn1tm1Sud
involves: 129 * C57BL/6
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
       
behavior/neurological
N
• mice exhibit no abnormal social behaviors, anxiety-like behaviors, locomotor activity and spatial learning (J:153748)
• increased repetitive grooming
• mice exhibit enhanced motor learning on a rotarod compared with wild-type mice
• mice fail to widen nests unlike wild-type mice
• however, nest height is normal

nervous system
• mice exhibit a decrease in the input-output relationship of excitatory synaptic transmission compared with wild-type mice
• mice exhibit decreased miniature excitatory postsynaptic current (mEPSC) frequency without a change in miniature inhibitory postsynaptic currents compared with wild-type mice
• however, mEPSC amplitude is normal

Mouse Models of Human Disease
OMIM IDRef(s)
Autism 209850 J:153748
Schizophrenia; SCZD 181500 J:153748