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Phenotypes Associated with This Genotype
Genotype
MGI:5428133
Allelic
Composition
Nrxn1tm1Sud/Nrxn1tm1Sud
Genetic
Background
involves: 129 * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nrxn1tm1Sud mutation (1 available); any Nrxn1 mutation (48 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
behavior/neurological
N
• mice exhibit no abnormal social behaviors, anxiety-like behaviors, locomotor activity and spatial learning
• mice exhibit enhanced motor learning on a rotarod compared with wild-type mice
• increased repetitive grooming
• mice fail to widen nests unlike wild-type mice
• however, nest height is normal

nervous system
• mice exhibit a decrease in the input-output relationship of excitatory synaptic transmission compared with wild-type mice
• mice exhibit decreased miniature excitatory postsynaptic current (mEPSC) frequency without a change in miniature inhibitory postsynaptic currents compared with wild-type mice
• however, mEPSC amplitude is normal

Mouse Models of Human Disease
OMIM ID Ref(s)
Autism 209850 J:153748
Schizophrenia; SCZD 181500 J:153748


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
05/17/2016
MGI 6.03
The Jackson Laboratory