Phenotypes Associated with This Genotype

Genotype
MGI:5427350

• Allelic Composition: Smarca1^tm1.1Pick/Smarca1^tm1.1Pick
• Genetic Background: involves: 129S4/SvJae * CD-1

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

nervous system

abnormal neuron differentiation ( J:183998 )

♀ • enhanced self-renewal in neuronal precursors at E13.5

abnormal neuronal precursor proliferation ( J:183998 )

♀ • increase in the proportion of mitotic cells in the ventricular zone at E15.5

♀ • increase in the number of BrdU positive cells in the neocortex at E13.5 and E15.5

♀ • increase in the number of proliferating apical and intermediate/basal progenitor cells and in intermediate/basal progenitor cells in the neocortex at E13.5 and E15.5, respectively

♀ • significantly shorter S phase in neuronal progenitors at E15.5

abnormal telencephalon development ( J:183998 )

♀ • expression analysis indicates potential changes to cell fate within layers V/VI at E15.5 and layer V at E17.5

abnormal cortical ventricular zone morphology ( J:183998 )

♀ • increased cell density at E15.5

increased brain weight ( J:183998 )

♀ • increase in brain:body mass ratio resulting from an increase in brain mass

abnormal cerebral cortex morphology ( J:183998 )

♀ • increase in cell density in cortical layers II/III, IV and V/VI at P7

♀ • cell densities are also increased in adults

thickened cerebral cortex ( J:183998 )

♀ • at P7 throughout the medial region

cardiovascular system

increased heart weight ( J:183998 )

♀

cellular

abnormal mitosis ( J:183998 )

♀ • significantly shorter S phase in neuronal progenitors at E15.5

abnormal neuron differentiation ( J:183998 )

♀ • enhanced self-renewal in neuronal precursors at E13.5

abnormal neuronal precursor proliferation ( J:183998 )

♀ • increase in the proportion of mitotic cells in the ventricular zone at E15.5

♀ • increase in the number of BrdU positive cells in the neocortex at E13.5 and E15.5

♀ • increase in the number of proliferating apical and intermediate/basal progenitor cells and in intermediate/basal progenitor cells in the neocortex at E13.5 and E15.5, respectively

♀ • significantly shorter S phase in neuronal progenitors at E15.5

growth/size/body

increased heart weight ( J:183998 )

♀