Phenotypes Associated with This Genotype

Genotype
MGI:5426791

• Allelic Composition: Maged1^tm1Tnab/Maged1^tm1Tnab
• Genetic Background: B6.129P2-Maged1^tm1Tnab

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

behavior/neurological phenotype ( J:183858 )

♀N • mice exhibit normal anxiety-like behavior, motor coordination and learning, and cognitive functions

decreased exploration in new environment ( J:183858 )

♀

anhedonia ( J:183858 )

♀ • in a sucrose preference test

behavioral despair ( J:183858 )

♀ • in a forced swim test, mice spend longer time in an immobile posture compared with wild-type mice

♀ • however, acute and chronic administration of sertraline or imipramine decreases the amount of time spent in immobile posture

decreased locomotor activity ( J:183858 )

♀ • in the home cage and a novel environment

♀ • however, acute and chronic treatment with sertraline or chronic imipramine treatment increases locomotor activity

social withdrawal ( J:183858 )

♀ • mice exhibit social withdrawal in a social interaction test compared with wild-type mice

♀ • however, acute and chronic treatment with sertraline or chronic imipramine treatment attenuates decreased social interaction

homeostasis/metabolism

abnormal serotonin level ( J:183858 )

♀ • serotonin turnover is reduced in the hippocampus and amygdala compared to in wild-type mice

♀ • potassium stimulation fails to increase serotonin levels in the prefrontal cortex and hippocampus unlike in wild-type mice

decreased serotonin level ( J:183858 )

♀ • in the prefrontal cortex

♀ • decreased 5-HIAA in the amygdala

increased serotonin level ( J:183858 )

♀ • in the hippocampus