Phenotypes Associated with This Genotype

Genotype
MGI:5426540

• Allelic Composition: Sox9^tm1Gsr/Sox9^tm1Gsr; Tg(Col2a1/Acan-rtTA,tetO-cre)#Vlf/0
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

skeleton

abnormal epiphyseal plate morphology ( J:183084 )

• with doxycycline treatment from E15.5 on, columnar zones are shortened in growth plates of mutants

chondrodystrophy ( J:183084 )

• with doxycycline treatment from E15.5 onward, severe dwarfism results

abnormal endochondral bone ossification ( J:183084 )

• endochondral bones stop elongating by E17.5 with doxycycline treatment from E15.5 onward

abnormal chondrocyte physiology ( J:183084 )

• chondrocytes lose ability to enlarge by E17.5 when doxycycline treatment takes place from E15.5 onward

• columnar cells stop proliferating at a rate 3 times greater than control cells with doxycycline treatment starting at E15.5; number of apoptotic cells in the columnar zone of growth plates is about 28 fold higher and about 5 times higher in the prehypertrophic zone of controls with 2 days of doxycycline treatment