Phenotypes Associated with This Genotype

Genotype
MGI:5320883

• Allelic Composition: Bcl11a^tm1Sbri/Bcl11a^tm1Sbri; Tg(Pou3f4-cre)32Cren/0
• Genetic Background: involves: CD-1

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

nervous system

abnormal neuron differentiation ( J:184011 )

• expression of late differentiation markers in dorsal spinal neurons is reduced indicating a defect in terminal differentiation

abnormal sensory neuron innervation pattern ( J:184011 )

• almost complete loss of small diameter nociceptive fibers in the dorsal horn

• reduction in the innervation of TrkA+ and aquaporin 1+ sensory neurons in the dorsal horn

abnormal neurite morphology ( J:184011 )

• in dorsal spinal neurons neurites are severely reduced and remaining structures often appear misshapen

• cultured neurons from the superficial dorsal horn show a decrease in the overall number, length and branching frequency of neurites

abnormal axon morphology ( J:184011 )

• almost complete loss of small diameter nociceptive fibers in the dorsal horn at E16.5

abnormal spinal cord dorsal horn morphology ( J:184011 )

• the superficial zone is invariably compressed and the nuclei appear compacted

• expression of late differentiation markers in dorsal spinal neurons is reduced indicating a defect in terminal differentiation

• in dorsal spinal neurons neurites are severely reduced and remaining structures often appear misshapen

• the density of DiI positive fibers is greatly reduced and the remaining fibers appear disorganized at E16.5

• almost complete loss of small diameter nociceptive fibers in the dorsal horn

abnormal excitatory postsynaptic currents ( J:184011 )

• the success rate for evoked currents is reduced in dorsal horn neurons

cellular

abnormal neuron differentiation ( J:184011 )

• expression of late differentiation markers in dorsal spinal neurons is reduced indicating a defect in terminal differentiation