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Phenotypes Associated with This Genotype
Genotype
MGI:5320791
Allelic
Composition
Jak2tm1Mohi/Jak2tm1Mohi
Tg(Mx1-cre)1Cgn/0
Genetic
Background
involves: C57BL/6 * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Jak2tm1Mohi mutation (0 available); any Jak2 mutation (16 available)
Tg(Mx1-cre)1Cgn mutation (6 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
hematopoietic system
• increased Gr-1/Mac-1+ cells in the spleen of pIpC-treated mice
• increased myeloid, megakaryocyte/erythroid and granulocyte/macrophage progenitors in the bone marrow and spleen of pIpC-treated mice
• increased granulocyte-macrophage progenitors in the spleen of pIpC-treated mice
• increased myeloid progenitors in the spleen of pIpC-treated mice
• in pIpC-treated mice with trilineage hyperplasia
• in pIpC-treated mice with increased number of megakaryocytes and clusters of immature erythroid precursors
• in the splenic red pulp of pIpC-treated mice
• 20-fold increase in CD71/Ter-119+ cells in the spleen of pIpC-treated mice
• in the bone marrow and spleen of pIpC-treated mice
• in pIpC-treated mice within 4 weeks and sustained for more than 20 weeks
• in pIpC-treated mice
• in pIpC-treated mice within 4 weeks and sustained for more than 20 weeks
• in pIpC-treated mice within 4 weeks and sustained for more than 20 weeks
• in pIpC-treated mice
• in pIpC-treated mice
• in the bone marrow and spleen of pIpC-treated mice
• in pIpC-treated mice
• in pIpC-treated mice
• in pIpC-treated mice
• in the bone marrow and spleen of pIpC-treated mice
• reticulin fibrosis in pIpC-treated mice
• in pIpC-treated mice with increased number of megakaryocytes and clusters of immature erythroid precursors
• in pIpC-treated mice
• in pIpC-treated mice
• fibrosis in pIpC-treated mice
• in pIpC-treated mice
• fibrosis in the splenic red and white pulp of pIpC-treated mice

immune system
• increased Gr-1/Mac-1+ cells in the spleen of pIpC-treated mice
• in the bone marrow and spleen of pIpC-treated mice
• in pIpC-treated mice
• in pIpC-treated mice
• reticulin fibrosis in pIpC-treated mice
• in pIpC-treated mice with increased number of megakaryocytes and clusters of immature erythroid precursors
• in pIpC-treated mice
• in pIpC-treated mice
• fibrosis in pIpC-treated mice
• in pIpC-treated mice
• fibrosis in the splenic red and white pulp of pIpC-treated mice

skeleton
• fibrosis in pIpC-treated mice
• fibrosis in the bone marrow cavity of pIpC-treated mice

Mouse Models of Human Disease
OMIM ID Ref(s)
Polycythemia Vera; PV 263300 J:183821


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
07/12/2016
MGI 6.04
The Jackson Laboratory