Mouse Genome Informatics
cn
    Jak2tm1Mohi/Jak2+
Tg(Mx1-cre)1Cgn/0

involves: C57BL/6 * CBA
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
       
hematopoietic system
• intermediate in pIpC-treated mice within 4 weeks and sustained for more than 20 weeks
• intermediate in pIpC-treated mice
• in pIpC-treated mice within 4 weeks and sustained for more than 20 weeks
• in pIpC-treated mice within 4 weeks and sustained for more than 20 weeks
• in pIpC-treated mice
• intermediate in pIpC-treated mice
• in the bone marrow and spleen of pIpC-treated mice
• intermediate in pIpC-treated mice
• intermediate in pIpC-treated mice
• increased Gr-1/Mac-1+ cells in the spleen of pIpC-treated mice
• intermediate increased myeloid, megakaryocyte/erythroid and granulocyte/macrophage progenitors in the bone marrow and spleen of pIpC-treated mice
• increased granulocyte-macrophage progenitors in the spleen of pIpC-treated mice
• increased myeloid progenitors in the spleen of pIpC-treated mice
• in the splenic red pulp of pIpC-treated mice
• 10-fold increase in CD71/Ter-119+ cells in the spleen of pIpC-treated mice
• intermediate in the bone marrow and spleen of pIpC-treated mice
• intermediate in pIpC-treated mice
• in the splenic red pulp of pIpC-treated mice
• in the bone marrow and spleen of pIpC-treated mice
• slight reticulin fibrosis in pIpC-treated mice
• in pIpC-treated mice with increased number of megakaryocytes and clusters of immature erythroid precursors
• intermediate in pIpC-treated mice
• intermediate in pIpC-treated mice
• fibrosis in pIpC-treated mice
• fibrosis in the splenic red and white pulp of pIpC-treated mice

immune system
• in the bone marrow and spleen of pIpC-treated mice
• intermediate in pIpC-treated mice
• intermediate in pIpC-treated mice
• increased Gr-1/Mac-1+ cells in the spleen of pIpC-treated mice
• slight reticulin fibrosis in pIpC-treated mice
• in pIpC-treated mice with increased number of megakaryocytes and clusters of immature erythroid precursors
• intermediate in pIpC-treated mice
• intermediate in pIpC-treated mice
• fibrosis in pIpC-treated mice
• fibrosis in the splenic red and white pulp of pIpC-treated mice

skeleton
• fibrosis in the bone marrow cavity of pIpC-treated mice
• mild fibrosis in older pIpC-treated mice

homeostasis/metabolism
• fibrosis in the splenic red and white pulp of pIpC-treated mice
• fibrosis in the bone marrow cavity of pIpC-treated mice

Mouse Models of Human Disease
OMIM IDRef(s)
Polycythemia Vera; PV 263300 J:183821