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Phenotypes Associated with This Genotype
Genotype
MGI:5317026
Allelic
Composition		 Tg(Atoh1-sb11)1Mtay/0
TgTn(sb-T2/Onc3)12740Njen/0
Trp53tm1Tyj/Trp53tm1Tyj
Genetic
Background		 involves: 129S2/SvPas * C3H * C57BL/6J * ICR
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(Atoh1-sb11)1Mtay mutation (0 available)
TgTn(sb-T2/Onc3)12740Njen mutation (1 available)
Trp53tm1Tyj mutation (12 available); any Trp53 mutation (237 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
neoplasm
increased medulloblastoma incidence ( J:181542 )
• in some mice with large cells, nuclear atypia and nuclear moulding typical of large cell/anaplastic histology

nervous system
increased medulloblastoma incidence ( J:181542 )
• in some mice with large cells, nuclear atypia and nuclear moulding typical of large cell/anaplastic histology

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Funding Information
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Send questions and comments to User Support. 		last database update
01/13/2026
MGI 6.24 		The Jackson Laboratory