Phenotypes Associated with This Genotype

Genotype
MGI:5312863

• Allelic Composition: Bmp4^tm1Jfm/Bmp4^tm1Jfm; H2az2^{Tg(Wnt1-cre)11Rth}/H2az2⁺
• Genetic Background: involves: 129S4/SvJaeSor * C57BL/6J * CBA/J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

skeleton

impaired osteoblast differentiation ( J:181229 )

• expression analysis indicates a defect in the transition from pre-osteoblast to osteoblast

large anterior fontanelle ( J:181229 )

• enlarged frontal fontanelle at E18.5

small interparietal bone ( J:181229 )

abnormal mandible morphology ( J:181229 )

• subtle mandibular defects at E18.5

cellular

impaired osteoblast differentiation ( J:181229 )

• expression analysis indicates a defect in the transition from pre-osteoblast to osteoblast

craniofacial

large anterior fontanelle ( J:181229 )

• enlarged frontal fontanelle at E18.5

small interparietal bone ( J:181229 )

abnormal mandible morphology ( J:181229 )

• subtle mandibular defects at E18.5

growth/size/body

abnormal mandible morphology ( J:181229 )

• subtle mandibular defects at E18.5