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Phenotypes Associated with This Genotype
Genotype
MGI:5310799
Allelic
Composition		 Rbpjtm1Hon/Rbpjtm1.1Hon
Gt(ROSA)26Sortm1(EYFP)Cos/Gt(ROSA)26Sor+
Hes1tm1(cre/ERT2)Lcm/Hes1+
Genetic
Background		 involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sortm1(EYFP)Cos mutation (24 available); any Gt(ROSA)26Sor mutation (1062 available)
Hes1tm1(cre/ERT2)Lcm mutation (0 available); any Hes1 mutation (23 available)
Rbpjtm1.1Hon mutation (1 available); any Rbpj mutation (191 available)
Rbpjtm1Hon mutation (2 available); any Rbpj mutation (191 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
endocrine/exocrine glands
endocrine/exocrine gland phenotype ( J:180310 )
N
• tamoxifen-treated mice exhibit normal pancreatic ductal morphology and pancreata mass
abnormal centroacinar cell of Langerhans morphology ( J:180310 )
• tamoxifen-treated mice exhibit a decrease in YFP+ centroacinar cells compared with control mice
increased pancreatic acinar cell number ( J:180310 )
• tamoxifen-treated mice exhibit an increase in YFP+ acinar cells compared with control mice
abnormal pancreas physiology ( J:180310 )
• tamoxifen-treated mice exhibit a rapid transformation of YFP+ centroacinar cells into acinar cells compared with control mice
• however, tamoxifen-treated mice exhibit normal centroacinar and acinar cells proliferation and apoptosis

digestive/alimentary system
abnormal centroacinar cell of Langerhans morphology ( J:180310 )
• tamoxifen-treated mice exhibit a decrease in YFP+ centroacinar cells compared with control mice
increased pancreatic acinar cell number ( J:180310 )
• tamoxifen-treated mice exhibit an increase in YFP+ acinar cells compared with control mice

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
01/06/2026
MGI 6.24 		The Jackson Laboratory