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Phenotypes Associated with This Genotype
Genotype
MGI:5308953
Allelic
Composition		 Ctnnb1tm2Kem/Ctnnb1tm3Kba
H2az2Tg(Wnt1-cre)11Rth/H2az2+
Genetic
Background		 involves: 129 * C57BL/6 * CBA/J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ctnnb1tm2Kem mutation (1 available); any Ctnnb1 mutation (51 available)
Ctnnb1tm3Kba mutation (0 available); any Ctnnb1 mutation (51 available)
H2az2Tg(Wnt1-cre)11Rth mutation (2 available); any H2az2 mutation (25 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
abnormal neuron differentiation ( J:178971 )
• differentiation of sensory neurons in the neural tube is defective
abnormal midbrain morphology ( J:178971 )
• milder defects than in conditional mutant mice homozygous for Ctnnb1tm2Kem at E12.5

craniofacial
abnormal craniofacial morphology ( J:178971 )
• milder defects than in conditional mutant mice homozygous for Ctnnb1tm2Kem at E12.5

embryo
embryo phenotype ( J:178971 )
N
• apical neural tube morphology is not disrupted at E12.5

cellular
abnormal neuron differentiation ( J:178971 )
• differentiation of sensory neurons in the neural tube is defective

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
01/06/2026
MGI 6.24 		The Jackson Laboratory