Phenotypes Associated with This Genotype

Genotype
MGI:5308808

• Allelic Composition: Pitx2^tm1.1Dmm/Pitx2^tm2Sac
• Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

embryo

abnormal embryo development ( J:181058 )

• abdominal and abdominal viscera defects similar to in Pitx2^tm2Sac homozygotes

abnormal embryo turning ( J:181058 )

• distal turning defect similar to in Pitx2^tm2Sac homozygotes

nervous system

abnormal neuronal migration ( J:181058 )

• mice lack migration of subthalamic neurons and recruitment of their projections into an expanded mammillotegmental tract

pituitary gland hypoplasia ( J:181058 )

abnormal nervous system tract morphology ( J:181058 )

• mice lack migration of subthalamic neurons and recruitment of their projections into an expanded mammillotegmental tract

cardiovascular system

abnormal heart morphology ( J:181058 )

• similar to in Pitx2^tm2Sac homozygotes

vision/eye

abnormal eye distance/ position ( J:181058 )

• medially displaced

craniofacial

abnormal tooth morphology ( J:181058 )

• severe

cellular

abnormal neuronal migration ( J:181058 )

• mice lack migration of subthalamic neurons and recruitment of their projections into an expanded mammillotegmental tract

endocrine/exocrine glands

pituitary gland hypoplasia ( J:181058 )

growth/size/body

abnormal tooth morphology ( J:181058 )

• severe

skeleton

abnormal tooth morphology ( J:181058 )

• severe