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Phenotypes Associated with This Genotype
involves: 129P2/OlaHsd * C57BL/6J * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Brca1tm1.1Jjon mutation (0 available); any Brca1 mutation (44 available)
Brca1tm1Brn mutation (2 available); any Brca1 mutation (44 available)
Tg(KRT14-cre)8Brn mutation (4 available)
Trp53tm1Brn mutation (6 available); any Trp53 mutation (141 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
• in transplanted tumors response to olaparib treatment is impaired compared to KB1P littermate controls but better than in KP mice
• transplanted tumors develop resistance to cisplatin and survival of transplanted mice is worse than that of mice transplanted with tumors from KB1P mice
• increased genomic instability in tumors compared to mice homozygous for Trp53tm1Brn and carrying Tg(KRT14-cre)8Brn (KP mice)
• compared to KB1P littermate controls homozygous
• most mammary tumors are poorly differentiated solid carcinomas
• a small percentage of tumors are classified as carcinosarcomas or lumen forming carcinomas
• markedly lower incidence compared to KB1P littermate controls
• however, no difference in the latency of mammary tumor development
• median latency is 197 days compared to 236 days in littermate controls homozygous for Brca1tm1Brn Trp53tm1Brn and carrying Tg(KRT14-cre)8Brn (KB1P)

Mouse Models of Human Disease
OMIM ID Ref(s)
Breast Cancer 114480 J:178595

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
MGI 6.01
The Jackson Laboratory