Mouse Genome Informatics

involves: 129P2/OlaHsd * C57BL/6J * FVB/N
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
• in transplanted tumors response to olaparib treatment is impaired compared to KB1P littermate controls but better than in KP mice
• transplanted tumors develop resistance to cisplatin and survival of transplanted mice is worse than that of mice transplanted with tumors from KB1P mice
• increased genomic instability in tumors compared to mice homozygous for Trp53tm1Brn and carrying Tg(KRT14-cre)8Brn (KP mice)
• compared to KB1P littermate controls homozygous
• most mammary tumors are poorly differentiated solid carcinomas
• a small percentage of tumors are classified as carcinosarcomas or lumen forming carcinomas
• markedly lower incidence compared to KB1P littermate controls
• median latency is 197 days compared to 236 days in littermate controls homozygous for Brca1tm1Brn Trp53tm1Brn and carrying Tg(KRT14-cre)8Brn (KB1P)
• however, no difference in the latency of mammary tumor development

Mouse Models of Human Disease
Breast Cancer 114480 J:178595