Phenotypes Associated with This Genotype

Genotype
MGI:5306355

• Allelic Composition: Kitl^tm2.1Sjm/Kitl^tm2.2Sjm; Tg(Tek-cre)12Flv/0
• Genetic Background: involves: BALB/cJ * C3H * C57BL/6 * C57BL/Ka * SJL

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

hematopoietic system

hematopoietic system phenotype ( J:180431 )

N • mice exhibit normal blood cell counts and bone marrow and spleen cellularity

decreased hematopoietic cell number ( J:180431 )

• to a greater extent than in Kitl^tm2.2Sjm heterozygotes in the bone marrow

• 1.7-2.1-fold in the liver of newborn mice

• 2-fold in the bone marrow of 1 month old mice

• 2.7-5.2-fold in the bone marrow of 8 week old mice

abnormal bone marrow cell physiology ( J:180431 )

• bone marrow cells from tamoxifen-treated mice used to repopulate irradiated mice exhibit reduced bone marrow-derived cell production (total, myeloid, T cell, and B cell)