Kitl^tm2.2Sjm
Targeted Allele Detail

Summary

• Symbol: Kitl^tm2.2Sjm
• Name: kit ligand; targeted mutation 2.2, Sean J Morrison
• MGI ID: MGI:5306338
• Synonyms: Scf^delta
• Gene: Kitl Location: Chr10:99851492-99936278 bp, + strand Genetic Position: Chr10, 51.4 cM
• Alliance: Kitl^tm2.2Sjm page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:180431
• Parent Cell Line: Bruce 4 (ES Cell)
• Strain of Origin: B6.Cg-Thy1^a

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Cre-mediated recombination removed exon 1. RT-PCR confirmed the absence of transcript expression in the liver. (J:180431)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Kitl Mutation: 92 strains or lines available

References

• Original: J:180431 Ding L, et al., Endothelial and perivascular cells maintain haematopoietic stem cells. Nature. 2012 Jan 26;481(7382):457-62
• All: 2 reference(s)