Phenotypes Associated with This Genotype

Genotype
MGI:5305777

• Allelic Composition: Gak^tm2Legr/Gak^tm2Legr; Tg(Nes-cre)1Kln/0
• Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * SJL

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

postnatal lethality, complete penetrance ( J:180119 )

• mice die between P3 and P21

nervous system

abnormal neuron differentiation ( J:180119 )

• mice exhibit decreased numbers of neuronal precursors due to reduced proliferation and migration compared with control mice

abnormal neuronal precursor proliferation ( J:180119 )

• reduced

abnormal cortical ventricular zone morphology ( J:180119 )

• at E15.5, cellular density in the forebrain and hindbrain cortex is reduced compared to in control mice

• at P1, mice exhibit reduced cellularity and thickness of the cerebral cortex compared with control mice

abnormal Ammon gyrus morphology ( J:180119 )

• decreased cell density

abnormal dentate gyrus morphology ( J:180119 )

• decreased cell density

decreased neuronal precursor cell number ( J:180119 )

• due to reduced proliferation and migration

behavior/neurological

lethargy ( J:180119 )

• some mice are sluggish at P3

cellular

abnormal neuron differentiation ( J:180119 )

• mice exhibit decreased numbers of neuronal precursors due to reduced proliferation and migration compared with control mice

abnormal neuronal precursor proliferation ( J:180119 )

• reduced