Phenotypes Associated with This Genotype

Genotype
MGI:5305470

• Allelic Composition: Adam10^tm1.1Khr/Adam10^tm1.1Khr; Tg(Mx1-cre)1Cgn/0
• Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * C57BL/6N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

hematopoietic system

small thymus ( J:179060 )

• in pIpC-treated mice

thymus hypoplasia ( J:179060 )

• in pIpC-treated mice

abnormal definitive hematopoiesis ( J:179060 )

• splenocytes and bone marrow cells from pIpC-treated mice exhibit increased colony-forming units compared with control mice

abnormal granulocyte differentiation ( J:179060 )

• non-cell-autonomous in pIpC-treated mice

abnormal T cell differentiation ( J:179060 )

• at an early stage in pIpC-treated mice

decreased double-positive T cell number ( J:179060 )

• in pIpC-treated mice

myeloid hyperplasia ( J:179060 )

• pIpC-treated mice exhibit an increase in Gr1+CD11b+ myeloid cells in the spleen compared with control mice

• however, no difference was observed in the bone marrow

decreased erythrocyte cell number ( J:179060 )

• in pIpC-treated mice

decreased hematocrit ( J:179060 )

• in pIpC-treated mice

decreased hemoglobin content ( J:179060 )

• in pIpC-treated mice

decreased T cell number ( J:179060 )

• in pIpC-treated mice

decreased CD4-positive, alpha-beta T cell number ( J:179060 )

• in pIpC-treated mice

decreased CD8-positive, alpha-beta T cell number ( J:179060 )

• in pIpC-treated mice

increased leukocyte cell number ( J:179060 )

• in pIpC-treated mice

increased neutrophil cell number ( J:179060 )

• in pIpC-treated mice

increased hematopoietic stem cell number ( J:179060 )

• in pIpC-treated mice

abnormal spleen morphology ( J:179060 )

• pIpC-treated mice exhibit myeloid infiltration in the spleen unlike in control mice

enlarged spleen ( J:179060 )

• severe in pIpC-treated mice with expansion of red pulp

increased spleen weight ( J:179060 )

• in pIpC-treated mice

spleen hyperplasia ( J:179060 )

• in pIpC-treated mice

increased spleen red pulp amount ( J:179060 )

• in pIpC-treated mice

skeleton

abnormal bone marrow morphology ( J:179060 )

• metatarsal bone marrow in pIpC-treated mice is filled with hematopoietic cells instead of being replaced with fat cells as in control mice

cellular

abnormal granulocyte differentiation ( J:179060 )

• non-cell-autonomous in pIpC-treated mice

immune system

abnormal granulocyte differentiation ( J:179060 )

• non-cell-autonomous in pIpC-treated mice

small thymus ( J:179060 )

• in pIpC-treated mice

thymus hypoplasia ( J:179060 )

• in pIpC-treated mice

abnormal T cell differentiation ( J:179060 )

• at an early stage in pIpC-treated mice

decreased double-positive T cell number ( J:179060 )

• in pIpC-treated mice

myeloid hyperplasia ( J:179060 )

• pIpC-treated mice exhibit an increase in Gr1+CD11b+ myeloid cells in the spleen compared with control mice

• however, no difference was observed in the bone marrow

decreased T cell number ( J:179060 )

• in pIpC-treated mice

decreased CD4-positive, alpha-beta T cell number ( J:179060 )

• in pIpC-treated mice

decreased CD8-positive, alpha-beta T cell number ( J:179060 )

• in pIpC-treated mice

increased leukocyte cell number ( J:179060 )

• in pIpC-treated mice

increased neutrophil cell number ( J:179060 )

• in pIpC-treated mice

abnormal spleen morphology ( J:179060 )

• pIpC-treated mice exhibit myeloid infiltration in the spleen unlike in control mice

enlarged spleen ( J:179060 )

• severe in pIpC-treated mice with expansion of red pulp

increased spleen weight ( J:179060 )

• in pIpC-treated mice

spleen hyperplasia ( J:179060 )

• in pIpC-treated mice

increased spleen red pulp amount ( J:179060 )

• in pIpC-treated mice

endocrine/exocrine glands

small thymus ( J:179060 )

• in pIpC-treated mice

thymus hypoplasia ( J:179060 )

• in pIpC-treated mice

growth/size/body

enlarged spleen ( J:179060 )

• severe in pIpC-treated mice with expansion of red pulp

increased spleen weight ( J:179060 )

• in pIpC-treated mice

spleen hyperplasia ( J:179060 )

• in pIpC-treated mice