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Phenotypes Associated with This Genotype
Genotype
MGI:5305469
Allelic
Composition
Adam10tm1.1Khr/Adam10tm1.1Khr
Csf3rtm1Link/Csf3rtm1Link
Tg(Mx1-cre)1Cgn/0
Genetic
Background
involves: 129S6/SvEvTac * 129X1/SvJ * C57BL/6 * C57BL/6N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Adam10tm1.1Khr mutation (0 available); any Adam10 mutation (39 available)
Csf3rtm1Link mutation (1 available); any Csf3r mutation (45 available)
Tg(Mx1-cre)1Cgn mutation (10 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
hematopoietic system
• in pIpC-treated mice to a lesser extent than in mice with wild-type Csf3r
• in pIpC-treated mice to a lesser extent than in mice with wild-type Csf3r
• in pIpC-treated mice to a lesser extent than in mice with wild-type Csf3r
• pIpC-treated mice exhibit an increase in Gr1+CD11b+ myeloid cells in the spleen compared with Csf3rtm1Link homozygotes

cellular
• in pIpC-treated mice to a lesser extent than in mice with wild-type Csf3r

immune system
• in pIpC-treated mice to a lesser extent than in mice with wild-type Csf3r
• in pIpC-treated mice to a lesser extent than in mice with wild-type Csf3r
• in pIpC-treated mice to a lesser extent than in mice with wild-type Csf3r
• pIpC-treated mice exhibit an increase in Gr1+CD11b+ myeloid cells in the spleen compared with Csf3rtm1Link homozygotes

growth/size/body
• in pIpC-treated mice to a lesser extent than in mice with wild-type Csf3r
• in pIpC-treated mice to a lesser extent than in mice with wild-type Csf3r


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
01/06/2026
MGI 6.24
The Jackson Laboratory