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Phenotypes Associated with This Genotype
Genotype
MGI:5302388
Allelic
Composition		 Dll4tm2.1Vlcg/Dll4+
Gt(ROSA)26Sortm2(cre/ERT2)Brn/Gt(ROSA)26Sor+
Genetic
Background		 involves: 129P2/OlaHsd * 129S6/SvEvTac * C57BL/6NTac
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dll4tm2.1Vlcg mutation (0 available); any Dll4 mutation (23 available)
Gt(ROSA)26Sortm2(cre/ERT2)Brn mutation (1 available); any Gt(ROSA)26Sor mutation (1083 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cardiovascular system
abnormal induced retina neovascularization ( J:177797 )
• retinal capillaries from tamoxifen-treated mice are more resistant to oxygen-induced vaso-obliteration compared with control capillaries
abnormal vascular regression ( J:177797 )
• tamoxifen-treated mice exhibit reduced capillary regression during normal developmental capillary remodeling compared with control mice

vision/eye
abnormal induced retina neovascularization ( J:177797 )
• retinal capillaries from tamoxifen-treated mice are more resistant to oxygen-induced vaso-obliteration compared with control capillaries

cellular
abnormal vascular regression ( J:177797 )
• tamoxifen-treated mice exhibit reduced capillary regression during normal developmental capillary remodeling compared with control mice

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
01/20/2026
MGI 6.24 		The Jackson Laboratory