Phenotypes Associated with This Genotype

Genotype
MGI:5302235

• Allelic Composition: Atp4a^m1Btlr/Atp4a^m1Btlr
• Genetic Background: involves: C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

growth/size/body

gastric cyst ( J:179090 )

• glandular and parietal, increasing in size and number with age

enlarged spleen ( J:179090 )

mortality/aging

mortality/aging ( J:179090 )

N • mice have a normal lifespan

hematopoietic system

hematopoietic system phenotype ( J:179090 )

N • mice exhibit normal leukocyte numbers and morphology

extramedullary hematopoiesis ( J:179090 )

• in the spleen

hypochromic anemia ( J:179090 )

• severe anemia occurs between 10 and 20 months of age

• however, anemia in mice fed a high-iron diet or a HCL-acidified drinking water is rescued

increased erythroid progenitor cell number ( J:179090 )

• in the bone marrow and spleen

abnormal erythrocyte morphology ( J:179090 )

• however, red blood cell indices are normalized by HCL-acidified drinking water

abnormal erythropoiesis ( J:179090 )

• compensatory erythropoiesis

decreased hematocrit ( J:179090 )

• not rescued by transplantation of wild-type bone marrow

decreased hemoglobin content ( J:179090 )

• until 8 weeks of age

• not rescued by transplantation of wild-type bone marrow

decreased mean corpuscular hemoglobin ( J:179090 )

decreased mean corpuscular volume ( J:179090 )

• not rescued by transplantation of wild-type bone marrow

increased red blood cell distribution width ( J:179090 )

anisocytosis ( J:179090 )

poikilocytosis ( J:179090 )

thrombocytosis ( J:179090 )

• in some mice

reticulocytosis ( J:179090 )

• until 8 weeks of age

abnormal spleen morphology ( J:179090 )

• due to extramedullary hematopoiesis

enlarged spleen ( J:179090 )

decreased erythrocyte osmotic fragility ( J:179090 )

• resistant to osmotic lysis

digestive/alimentary system

abnormal stomach morphology ( J:179090 )

• indurated and enlarged

enlarged stomach ( J:179090 )

gastric cyst ( J:179090 )

• glandular and parietal, increasing in size and number with age

increased stomach pH ( J:179090 )

homeostasis/metabolism

increased circulating erythropoietin level ( J:179090 )

abnormal iron homeostasis ( J:179090 )

• when fed an iron-deficient diet, mice exhibit reduced iron absorption compared with wild-type mice

• however, mice fed a regular diet exhibit normal iron absorption

decreased circulating iron level ( J:179090 )

• however, serum iron levels are rescued by HCL-acidified drinking water

immune system

abnormal spleen morphology ( J:179090 )

• due to extramedullary hematopoiesis

enlarged spleen ( J:179090 )