Phenotypes for a Apoe Ccr2 MGI:5297861 MGI Mouse

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Phenotypes Associated with This Genotype

Allelic Composition	A^y/a Apoe^tm1Unc/Apoe^tm1Unc Ccr2^tm1Mae/Ccr2^tm1Mae
Genetic Background	involves: 129P2/OlaHsd * C57BL/6J * KK/TaJcl

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
a mutation (166 available); any a mutation (468 available)
Apoe^tm1Unc mutation (34 available); any Apoe mutation (163 available)
A^y mutation (14 available); any a mutation (468 available)
Ccr2^tm1Mae mutation (3 available); any Ccr2 mutation (43 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

homeostasis/metabolism

homeostasis/metabolism phenotype ( J:177084 )

N	• mutants are protected against the metabolic syndrome, atherosclerosis, and diabetic nephropathy that develops in A^y/a Apoe^tm1Unc double mutants

increased circulating leptin level ( J:177084 )

increased circulating cholesterol level ( J:177084 )

decreased circulating adiponectin level ( J:177084 )

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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