Phenotypes Associated with This Genotype

Genotype
MGI:5297719

• Allelic Composition: Kit^W-v/Kit⁺; Tg(Mt1-RET)304Ina/0
• Genetic Background: involves: BALB/c * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

decreased tumor-free survival time ( J:88074 )

• average lifespan of mutants with tumors is 13.2 +/- 4.8 months

• 9.8% and 40.9% of mutants die of growing melanoma within 12 and 18 months of birth, respectively

neoplasm

increased melanoma incidence ( J:88074 )

• 68.9% of mutants develop melanocytic tumors

• mutants are on average tumor free until 11.9 months of age

decreased tumor incidence ( J:88074 )

• mutants exhibit suppression of melanoma development compared to single Tg(Mt1-RET)304Ina/0 mice, showing reduced tumor growth and prolonged survival

• 31.1% of mutants do not develop tumors throughout their lifetime