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Phenotypes Associated with This Genotype
Genotype
MGI:5297584
Allelic
Composition		 Jam3tm1Rha/Jam3tm1.1Chav
Tg(Spo11-cre)D5Mpel/0
Genetic
Background		 involves: 129P2/OlaHsd * BALB/c * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Jam3tm1.1Chav mutation (0 available); any Jam3 mutation (24 available)
Jam3tm1Rha mutation (0 available); any Jam3 mutation (24 available)
Tg(Spo11-cre)D5Mpel mutation (1 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
reproductive system
abnormal manchette morphology ( J:166888 )
• cytoskeletal defects are observed in round spermatids; F-actin appears uniformly distributed (disorganized) within the cytoplasm, not localized to restricted zones of the cells (polarized)
decreased male germ cell number ( J:166888 )
• from 2 months of age onward, males show a strong decrease in sperm number from 90 to 95% relative to control males
decreased spermatid number ( J:166888 )
• rare elongating spermatids are detected in tubules in the testis
• degenerating spermatids and spermatocytes are observed in seminiferous tubules
increased male germ cell apoptosis ( J:166888 )
• widespread germ cell apoptosis is observed in testes
small testis ( J:166888 )
• reduction in testis size is observed in analyses at 7 months of age
arrest of spermatogenesis ( J:166888 )
• more than 80-90% of tubules are arrested at round stage of spermatid differentiation

endocrine/exocrine glands
small testis ( J:166888 )
• reduction in testis size is observed in analyses at 7 months of age

cellular
abnormal manchette morphology ( J:166888 )
• cytoskeletal defects are observed in round spermatids; F-actin appears uniformly distributed (disorganized) within the cytoplasm, not localized to restricted zones of the cells (polarized)
decreased male germ cell number ( J:166888 )
• from 2 months of age onward, males show a strong decrease in sperm number from 90 to 95% relative to control males
decreased spermatid number ( J:166888 )
• rare elongating spermatids are detected in tubules in the testis
• degenerating spermatids and spermatocytes are observed in seminiferous tubules
increased male germ cell apoptosis ( J:166888 )
• widespread germ cell apoptosis is observed in testes

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
03/18/2025
MGI 6.24 		The Jackson Laboratory